Much as I've enjoyed being Ezio for two games, soon to be three, I'm looking forward to either getting a new character in a new time period, or just playing as Desmond in modern-day, regardless of the city. If they don't go fully modern-day, I'd like Assassin's Creed III to be set in Japan. Though, I wonder if the Yakuza would be Templar or Assassin-allied.
I don't know if I'm going to be getting this on day 1, since it releases on the same day as Saints Row 3, and only three days after Skyrim. It all depends on what the pre-order bonus is like. I'm actually considering putting Skyrim off, since I don't know if I'll be able to get my computer upgraded by then. The November release schedule is fucked. At least Gears 3 comes out in September.