Fuck that shit, I have to reply.
Jesus fucking christ, let me make an announcement, people don't seem to understand what I'm saying.
I believe there WILL be another city except Los Santos
However, that doesn't necessarily mean it has to be SF or LV. It could be any other city. What I was saying is that San Diego is MORE LIKELY than SF or LV. Why you may ask? Because the game is loosely based on Southern California. Therefore it would make more sense. I know it's not impossible for SF and LV, but the chances are LOWER. It could still be the largest and most ambitious game, but that doesn't mean they have to include the same fucking cities from a previous game, just because they were there before. For all we know, "largest and most ambitious" could be entirely based on things to do in the game, mechanics and graphics. However it could also have something to do with the map, but who knows for certain.